Tell your doctor about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Marfan syndrome is caused by a change in the gene that controls how the body makes fibrillin, an essential component of connective tissue that contributes to its strength and elasticity. Make dose adjustments as needed unless the patient is volume depleted. How Does Marfan Sydrome Affect Lifestyle Choices? How should I take Losartan Potassium and Hydrochlorothiazide tablets? procyclidine price no insurance procyclidine
Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. In most cases, Marfan syndrome is inherited from a parent, but 1 in 4 cases occurs in people with no known family history of the disease. It occurs equally in men and women, who have a 50% risk of passing on the gene to their children. Marfan syndrome is present at birth, but may not be diagnosed until adolescence or later. Everyone with Marfan syndrome has the same defective gene, but not everyone experiences the same symptoms to the same degree. Closely monitor blood pressure, renal function, and electrolytes in patients on Losartan Potassium and Hydrochlorothiazide and other agents that affect the RAS.
Distribution: The volume of distribution of losartan and the active metabolite is about 34 liters and 12 liters, respectively. Americans. It is found in people of all races and ethnic backgrounds. Allergic reaction. Symptoms of an allergic reaction are swelling of the face, lips, throat, or tongue. Get emergency medical help right away and stop taking Losartan Potassium and Hydrochlorothiazide tablets. Advise patient to try to take each dose at about the same time each day.
Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Respiratory, thoracic and mediastinal disorders: Nasal congestion, pharyngitis, sinus disorder, respiratory distress including pneumonitis and pulmonary edema. St John's Wort: May decrease the serum concentration of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling.
Eye disorders: Xanthopsia, transient blurred vision. Losartan Potassium and Hydrochlorothiazide tablets can be taken with or without food. Hypotension 7%; orthostatic hypotension 4%. May use alone or in combination with other antihypertensive agents. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Deferasirox: May decrease the serum concentration of CYP3A4 Substrates. Well absorbed. Food decreases absorption but has only minor effects on losartan AUC or AUC of active metabolite. Systemic bioavailability is about 33%. T max is 1 h losartan and 3 to 4 h metabolite. If you have kidney problems, you may see a worsening in how well your kidneys work. Call your doctor if you get swelling in your feet, ankles, or hands, or unexplained weight gain. Medications are typically not used to treat Marfan syndrome. However, your doctor may prescribe a beta-blocker, which decreases the forcefulness of the heartbeat and the pressure within the arteries, thus preventing or slowing the enlargement of the aorta. Beta-blocker therapy is usually started when the person with Marfan syndrome is young. The double-blind treatment period lasted up to 8 weeks. The incidence of cough is shown in Table 1 below. Advise patient to monitor and record BP and pulse at home and to inform health care provider if abnormal measurements are noted. Advise patient to take record of BP and pulse to each follow-up visit. Long arms, legs, fingers, and toes and flexible joints.
The scans can also be used to check the lower back for signs of dural ectasia, a back problem that is common in people with Marfan syndrome. Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. Stagger the dosage of hydrochlorothiazide and the resin such that hydrochlorothiazide is administered at least 4 hours before or 4 to 6 hours after the administration of the resin. Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Gastrointestinal disorders: Dyspepsia, abdominal pain, gastric irritation, cramping, diarrhea, constipation, nausea, vomiting, pancreatitis, sialoadenitis. Read the Patient Information Leaflet if available from your pharmacist before you start taking losartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Heparin Low Molecular Weight: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. This information is generalized and not intended as specific medical advice. See “What is the most important information I should know about Losartan Potassium and Hydrochlorothiazide tablets? There are no dosage adjustments provided in the manufacturer's labeling. cardura
There is also an AT 2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Neither losartan nor its principal active metabolite exhibits any partial agonist activity at the AT 1 receptor, and both have much greater affinity about 1000-fold for the AT 1 receptor than for the AT 2 receptor. In vitro binding studies indicate that losartan is a reversible, competitive inhibitor of the AT 1 receptor. The active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT 1 receptor. Plasma concentrations may be increased by losartan, resulting in an increase in the pharmacologic and adverse effects of lithium. The effect of losartan is substantially present within one week but in some studies the maximal effect occurred in 3 to 6 weeks. In long-term follow-up studies without placebo control the effect of losartan appeared to be maintained for up to a year. There is no apparent rebound effect after abrupt withdrawal of losartan. There was essentially no change in average heart rate in losartan-treated patients in controlled trials. CloZAPine: CYP1A2 Inhibitors Weak may increase the serum concentration of CloZAPine. Shake suspension well before measuring and administering prescribed dose. Use dosing syringe, dosing spoon, or dosing cup to measure and administer dose. Return suspension to refrigerator immediately after measuring dose. Losartan Potassium and Hydrochlorothiazide contains hydrochlorothiazide which can cause hypokalemia, hyponatremia and hypomagnesemia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. Losartan Potassium and Hydrochlorothiazide also contains losartan which can cause hyperkalemia. The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient. The exposed fetus should be monitored for fetal growth, amniotic fluid volume, and organ formation. Infants exposed in utero should be monitored for hyperkalemia, hypotension, and oliguria exchange transfusions or dialysis may be needed. These adverse events are generally associated with maternal use in the second and third trimesters. Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of angiotensin II receptor antagonists or thiazide diuretics. Monitor lithium levels in patients receiving Losartan Potassium and Hydrochlorothiazide and lithium. Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus. Store tablets at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. CYP2C9 Inducers Strong: May increase the metabolism of CYP2C9 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. There may be new information. This leaflet does not take the place of talking with your doctor about your condition and treatment. Aurobindo Pharma USA, Inc. Caution patient not to take any prescription or OTC medications, potassium-containing salt substitutes, potassium supplements, dietary supplements, or herbal preparations unless advised by health care provider.
Black patients: When used to reduce the risk of stroke in patients with HTN and LVH, may not be effective in the black population. Sarilumab: May decrease the serum concentration of CYP3A4 Substrates. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. HER2 in order to develop more targeted treatments for women whose breast cancers are not HER2-positive and therefore do not respond to Herecptin. Genetic testing alone cannot tell you if you have Marfan syndrome, as there are other connective tissue disorders. LVH can happen from several things. High blood pressure is the most common cause of LVH. Emotional considerations. Learning you have Marfan syndrome may cause you to feel angry, frightened or sad. You may need to make changes in your lifestyle and adjust to having careful medical follow-up the rest of your life. You may have financial concerns. You also need to consider the risk to your future children. The National Marfan Foundation can provide support. brand arava pills
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue losartan as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. Cases of cough, including positive re-challenges, have been reported with the use of losartan in postmarketing experience. Minor increases in BUN or serum creatinine, small decreases in Hgb and Hct, occasional elevations in liver enzymes and serum bilirubin postmarketing. Hypoglycemia 14%; hyperkalemia 7%; weight gain 4%; hyponatremia postmarketing. CycloSPORINE Systemic: Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of CycloSPORINE Systemic. Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Losartan Potassium and Hydrochlorothiazide tablets for a condition for which it was not prescribed. Do not give Losartan Potassium and Hydrochlorothiazide tablets to other people, even if they have the same symptoms that you have. Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine.
Blood and the lymphatic system disorders: Anemia, aplastic anemia, hemolytic anemia, leukopenia, agranulocytosis. Take Losartan Potassium and Hydrochlorothiazide tablets exactly as prescribed by your doctor. Your doctor may change your dose if needed. Because AGTR1 is involved in the constriction of vessels, its activity is blocked by a class of drugs called angiotensin receptor blockers, which include losartan, the drug tested in this study. Advise patient that medication may cause dizziness or light-headedness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined. In efforts to control blood pressure, the patients in both arms of the LIFE study were coadministered hydrochlorothiazide the majority of time they were on study drug 73. Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. will domperidone
We have lots of patients who get treated for breast cancer and take anti-hypertensives, so you would expect to see that pop out as an indicator of good outcomes. The incidence of some adverse reactions varied based on the underlying disease state. Notations are made, where applicable, for data derived from trials conducted in type 2 diabetic nephropathy and hypertensive patients, respectively. Daniel Rhodes, PhD, a research investigator in the Michigan Center for Translational Pathology and the lead author of the study, which appears in the June 1 edition of Proceedings of the National Academy of Sciences. Rhodes is also the founder and CEO of a genomics company, Compendia Biosciences. ACE Inhibitors. Angiotensin II Receptor Blockers may increase the serum concentration of ACE Inhibitors. Management: In US labeling, use of telmisartan and ramipril is not recommended. It is not clear if any other combination of an ACE inhibitor and an ARB would be any safer. Consider alternatives to the combination when possible. After 6 weeks of therapy, more patients who received the combination regimen reached target diastolic blood pressure than those who received the monotherapy regimen 29. Fluconazole: May decrease the serum concentration of Losartan. Specifically, fluconazole may decrease the serum concentration of E3174, the more potent active metabolite of losartan. Co, Inc, Whitehouse Station, NJ, 2015. What should I tell my doctor before taking Losartan Potassium and Hydrochlorothiazide tablets? Renal impairment: Use with caution with preexisting renal insufficiency. Caution patient not to change the dose or stop taking unless advised by health care provider. Thiazides cross the placental barrier and appear in cord blood. Instruct patient to immediately discontinue drug and notify health care provider if any of the following occur: swelling of the face, lips, eyelids, or tongue, difficulty breathing, or difficulty swallowing. At the end of study or at the last visit before a primary endpoint, 77% of the group treated with losartan and 73% of the group treated with atenolol were still taking study medication. The AUC of active metabolite following oral losartan was not affected by erythromycin, an inhibitor of P450 3A4, but the AUC of losartan was increased by 30%.
Total plasma Cl of losartan is reduced about 50% and oral bioavailability is increased 2 times. A lower starting dose is recommended. Naftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. These effects can occur even if grapefruit is not consumed at the same time of the losartan dose. This interaction may occur at any time in your treatment with losartan if grapefruit or grapefruit juice is consumed. Documentation of allergenic cross-reactivity for angiotensin receptor blockers is limited. Losartan Potassium and Hydrochlorothiazide can pass into your milk and may harm your baby. You and your doctor should decide if you will take Losartan Potassium and Hydrochlorothiazide tablets or breastfeed. You should not do both. Keep Losartan Potassium and Hydrochlorothiazide tablets in a tightly closed container, and keep Losartan Potassium and Hydrochlorothiazide tablets out of the light. Scapa E. Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. Dronabinol: CYP2C9 Inhibitors Moderate may increase the serum concentration of Dronabinol. Nervous system disorders: Dysgeusia, headache, migraine, paraesthesias. Heparin: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Cough 11%; bronchitis 10%; upper respiratory tract infection 8%; sinusitis 6%; dry cough postmarketing. What is the most important information I should know about Losartan Potassium and Hydrochlorothiazide tablets? Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. AUCs for losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage 100 mg. Adults: No dosage adjustment necessary unless the patient is volume depleted; monitor closely. Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. ramipril
Losartan Potassium and Hydrochlorothiazide. Monitor renal function periodically in these patients. Bosentan: May decrease the serum concentration of CYP3A4 Substrates. Drospirenone: Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of Drospirenone. These considerations may guide selection of therapy. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Persistent dry cough has been associated with ACE-inhibitor use and in practice can be a cause of discontinuation of ACE-inhibitor therapy. Two prospective, parallel-group, double-blind, randomized, controlled trials were conducted to assess the effects of losartan on the incidence of cough in hypertensive patients who had experienced cough while receiving ACE-inhibitor therapy. Ciprofloxacin Systemic: Angiotensin II Receptor Blockers may enhance the arrhythmogenic effect of Ciprofloxacin Systemic. Ames microbial mutagenesis assay and the V-79 Chinese hamster lung cell mutagenesis assay. In addition, there was no evidence of direct genotoxicity in the in vitro alkaline elution assay in rat hepatocytes and in vitro chromosomal aberration assay in Chinese hamster ovary cells at noncytotoxic concentrations. Note: Marfan syndrome is not the only genetic disorder that affects connective tissue. Administer without regard to meals. Administer with food if GI upset occurs. Injury or death of unborn babies. See “What is the most important information I should know about Losartan Potassium and Hydrochlorothiazide tablets? Losartan plasma levels may be elevated, increasing the antihypertensive and adverse effects. Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Cardiac disorders: Palpitation, tachycardia.
Grapefruit juice may decrease the amount of active losartan in your blood. Drugs that act on the renin-angiotensin system can cause injury and death to the developing fetus. Discontinue as soon as possible once pregnancy is detected. The use of drugs which act on the renin-angiotensin system are associated with oligohydramnios. Oligohydramnios, due to decreased fetal renal function, may lead to fetal lung hypoplasia and skeletal malformations. Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Losartan Potassium and Hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular CV events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan and hydrochlorothiazide. Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor. Initiation of Losartan Potassium and Hydrochlorothiazide is not recommended for patients with hepatic impairment because the appropriate starting dose of losartan, 25 mg, is not available. How should I store Losartan Potassium and Hydrochlorothiazide tablets? In patients who experience a decline in renal function, discontinuation of AR antagonist therapy is usually not required provided there is symptomatic improvement of the heart failure and renal deterioration is well-tolerated. Transient hypotension is also not a contraindication to further treatment with AR antagonists, since therapy can usually be reinstated without difficulty after blood pressure stabilizes. Do not coadminister aliskiren with Losartan Potassium and Hydrochlorothiazide in patients with diabetes. June 1, 2009 -- Researchers at the University of Michigan have identified a gene that may be involved in as many as one in five cancers. And the gene could be blocked by a common drug. Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. store levothyroxine polo
Are There Physical Traits in People With Marfan Syndrome? CYP3A4 Inducers Strong: May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Losartan pharmacokinetics have been investigated in the elderly 65 to 75 years and in both genders. Plasma concentrations of losartan and its active metabolite are similar in elderly and young hypertensives. Plasma concentrations of losartan were about twice as high in female hypertensives as male hypertensives, but concentrations of the active metabolite were similar in males and females. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Digestive: Hepatitis has been reported rarely in patients treated with losartan. CYP3A4 Inducers Moderate: May decrease the serum concentration of CYP3A4 Substrates. Blood pressure reduction measured at trough was similar for both treatment groups but blood pressure was not measured at any other time of the day. At the end of study or at the last visit before a primary endpoint, the mean blood pressures were 144. The decision to perform surgery is based on the size of the aorta, expected normal size of the aorta, rate of aortic growth, age, height, gender, and family history of aortic dissection. Surgery involves replacing the dilated portion of the aorta with a graft, a piece of man-made material that is inserted to replace the damaged or weak area of the blood vessel. Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Brimonidine Topical: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Tell your doctor if your condition does not improve or if it worsens for example, your blood pressure readings increase. Genetic counseling should be performed prior to pregnancy because Marfan syndrome is an inherited condition. Pregnant women with Marfan syndrome are also considered high-risk cases. If the aorta is normal size, the risk for dissection is lower, but not absent. Those with even slight enlargement are at higher risk and the stress of pregnancy may cause more rapid dilation. Careful follow-up, with frequent blood pressure checks and monthly echocardiograms is required during pregnancy. If there is rapid enlargement or aortic regurgitation, may be required. Your doctor will discuss with you the best method of delivery with you.
There was no difference in response for men and women or in patients over or under 65 years of age. In these cases, another medication called a may be recommended. What are the ingredients in Losartan Potassium and Hydrochlorothiazide tablets? Other diagnostic tests for Marfan syndrome include a slit lamp in which the doctor will check for dislocated lenses. These could cause you to have low blood pressure. Respective AUCs for losartan, its active metabolite and hydrochlorothiazide at these dosages in rats were approximately 35, 10 and 10 times greater than those achieved in humans with the administration of 100 mg of losartan in combination with 25 mg hydrochlorothiazide. Antifungal Agents Azole Derivatives, Systemic: May decrease the metabolism of Losartan. Applicable Isavuconazonium considerations are addressed in separate monographs. Exceptions: Isavuconazonium Sulfate. Instruct patient in BP and pulse measurement skills. can you vasodilan in uk
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Trimethoprim: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Canadian labeling: Use is not recommended. The use of thiazide diuretics is commonly associated with loss of electrolytes, most significantly potassium but also sodium, chloride, bicarbonate, and magnesium. The loss of other electrolytes such as phosphate, bromide and iodide is usually slight. Potassium and magnesium depletion may lead to cardiac arrhythmias and cardiac arrest. Other electrolyte-related complications include metabolic alkalosis and hyponatremia, which are rarely life-threatening. Therapy with thiazide diuretics should be administered cautiously in patients with or predisposed to fluid and electrolyte depletion, including patients with primary or secondary aldosteronism may have low potassium levels; those with severe or prolonged diarrhea or vomiting; and those with poor nutritional status. Fluid and electrolyte abnormalities should be corrected prior to initiating therapy, and blood pressure as well as serum electrolyte concentrations monitored periodically and maintained at normal ranges during therapy. Patients should be advised to immediately report signs and symptoms of fluid or electrolyte imbalance, including dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, or gastrointestinal disturbances such as nausea and vomiting. Digitalized patients and patients with a history of ventricular arrhythmias should be monitored carefully, since development of hypokalemia may be particularly dangerous in these patients. The risk of hypokalemia may be minimized by slow diuresis, a lower thiazide dosage, potassium supplementation, or combined use with a potassium-sparing diuretic. condyline online buy condyline
Eplerenone: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Neonates with a history of in utero exposure to Losartan Potassium and Hydrochlorothiazide: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion. AR antagonists, and the patient should be hemodynamically stable. Ideally, patients at risk for excessive hypotension should initiate AR antagonist therapy under close medical supervision, preferably with a lower dose, and followed closely for the first 2 weeks of treatment and whenever the dosage of AR antagonist or diuretic is increased.
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan Potassium and Hydrochlorothiazide as soon as possible. While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage such as orange juice. enew.info plaquenil
Losartan Potassium and Hydrochlorothiazide tablets and certain other medicines may interact with each other. Caution patient that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to excessive fall in BP resulting in light-headedness or fainting. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment. Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered.